M Bessire, S Borel, G Fabre, L Carraça… - The Plant Cell …, 2011 - Am Soc Plant Biol Although the multilayered structure of the plant cuticle was discovered many years ago, the molecular basis of its formation and the functional relevance of the layers are not understood. Here, we present the permeable cuticle1 (pec1) mutant of Arabidopsis thaliana, which displays ... Related articles - All 3 versions
VS Donnenberg, L Zimmerlin… - Cancer Stem Cells in …, 2011 - Springer Abstract There can be no cure for epithelial cancer until there is a significant therapeutic index that separates the most therapy-resistant cells within tumors, and the cells that mediate functions essential to life. The cancer stem cell paradigm explains tumor heterogeneity and has led ...
[HTML] from plos.orgSE Hensley, SR Das, JS Gibbs, AL Bailey… - PLoS One, 2011 - dx.plos.org Drugs inhibiting the influenza A virus (IAV) neuraminidase (NA) are the cornerstone of anti-IAV chemotherapy and prophylaxis in man. Drug-resistant mutations in NA arise frequently in human isolates, limiting the therapeutic application of NA inhibitors. Here, we show that antibody- ... Cited by 5 - Related articles - Cached - All 5 versions
GJP Dijkgraaf, B Alicke, L Weinmann, T Januario… - Cancer research, 2011 - AACR Inappropriate Hedgehog (Hh) signaling has been directly linked to medulloblastoma (MB), a common malignant brain tumor in children. GDC-0449 is an Hh pathway inhibitor (HPI) currently under clinical investigation as an anticancer agent. Treatment of a MB patient with GDC- ... Cited by 4 - Related articles - All 4 versions
SL Mitchell, N Seoudi, DCS Hutchison… - Thorax, 2011 - thorax.bmj.com Undiagnosed chronic obstructive pulmonary disease (COPD) is a major public health issue, as it leads to patients missing out on appro- priate preventive and therapeutic inter- ventions.1e3 The ratio of diagnosed/predicted COPD prevalence differs widely between ... Cited by 1 - Related articles - All 3 versions
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