MA LEA, J CHACKO, S BOLIKAL… - Anticancer …, 2011 - ar.iiarjournals.org A report that effects of butyrate on some cells may be mediated by activation of AMP-activated protein kinase (AMPK) prompted this study which examines if other AMPK activators can induce differentiation and inhibit proliferation of colon cancer cells in a manner similar to ... Related articles - All 3 versions
[PDF] from unt.eduDF Egan, DB Shackelford, MM Mihaylova, S Gelino… - Science, 2011 - sciencemag.org ... S2), which is consistent with recent proteomic analyses (9). To examine ULK1 in vivo phosphorylation sites, we used tandem mass spectrometry on epitope-tagged ULK1 isolated from cells treated with or without the mitochondrial complex I inhibitor phenformin (10). ... Cited by 31 - Related articles - All 7 versions
Y Sogame, A Kitamura, M Yabuki… - Biomedicine & …, 2011 - Elsevier ... The present study was designed to compare hepatic uptake of two biguanides, metformin and phenformin, in vitro and in vivo. ... Keywords: Metformin; Phenformin; Hepatic uptake. Article Outline. 1. Introduction 2. Materials and methods 2.1. Compounds 2.2. ... Related articles
CAW Schneider - 2011 - gradworks.umi.com ... Two compounds, phenformin and rotenone, inhibit mitochondrial complex I. These compounds selectively repressed insulin and Wnt signaling. AICAR, a direct AMPK activator, inhibited responses induced by all growth factors. ... Cached
JG Heaf… - Clinical Diabetes, 2011 - Am Diabetes Assoc ... Assertions 1 and 2: “Phenformin, a biguanide, causes LA.”. ...Phenformin, one of the earliest biguanides, was rapidly discovered to cause an increased incidence of LA (129/100,000 patient-years), 1 a life-threatening condition with a mortality of 50%. ...