K Maeda, J Takano, Y Ikeda, T Fujita… - Clinical Pharmacology …, 2011 - nature.com Microdosing studies are effective in enabling the early identification of the pharmacokinetic properties of compounds administered to humans. However, the nonlinearity of the pharmacokinetics between microdose and therapeutic dose, attributable to the saturation of metabolic enzymes and ... All 3 versions
SF Noujaim, JA Stuckey… - Cardiovascular …, 2011 - cardiovascres.oxfordjournals.org Methods and results We used comparative molecular modelling and ligand docking of the three-dimensional structures of quinidine and chloroquine in the intracellular domain of Kir2.1. Simulations predicted that chloroquine effectively blocks potassium flow by ... Cited by 1 - Related articles - All 4 versions
SM Wang, CL Blake, NA Malek, PW Angus… - …, 2011 - espace.library.uq.edu.au Wang, SM, Blake, CL, Malek, NA, Angus, PW and Ghabrial, H. (2001) Differential inhibition of human CYP1A1 AND CYP1A2 by quinidine and quinine.. Xenobiotica, 31 11: 757-767. ... Wang, SM Blake, CL Malek, NA Angus, PW Ghabrial, H. ... Differential inhibition of ... Cached - All 3 versions
GE O'Hara, F Philippon, M Gilbert… - The Journal of …, 2011 - jcp.sagepub.com Propafenone and its 5-hydroxy metabolite exhibit different electrophysiological properties. Objectives of the CAQ-PAF study were (1) to develop a strategy favoring propafenone instead of 5-hydroxypropafenone in plasma following oral administration of propafenone and (2) to evaluate the potential of ... Related articles - All 3 versions
I Sziráki, F Erdő, E Beéry, PM Molnár… - Journal of …, 2011 - jbx.sagepub.com 1solvo biotechnology, szeged, hungary 2department of biochemistry, faculty of Medicine, university of szeged, hungary 3institute of biophysics, biological research Center, szeged, hungary 4department of Medical Chemistry, faculty of Medicine, university of szeged, szeged, hungary 5trans- ...
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