K Sarkar… - … and Assembly, Biological and Medical Physics, …, 2011 - Springer Hypoxia is defined as a reduction in the amount of oxygen available to a cell, tissue, or organism. Normal tissue function depends on adequate delivery of oxygen and nutrients and removal of toxic metabolic by-products through blood vessels. The transcription factor, ... Related articles - All 3 versions
GL Semenza - Studies on Renal Disorders, 2011 - Springer Abstract The hypoxia-inducible factors (HIFs) are transcriptional activators that mediate homeostatic responses to hypoxia. At the cellular level, HIF-1 mediates adaptive metabolic responses to hypoxia that serve to maintain energy and redox homeostasis by reducing mitochondrial ... Related articles - All 2 versions
Y Xue, NL Li, JY Yang, Y Chen… - American Journal of …, 2011 - Am Physiological Soc We have previously demonstrated the roles of RhoA, Rac1, and Cdc42 in hypoxia-driven angiogenesis. However, the role of oncogenes in hypoxia signaling is poorly understood. Given the importance of Rho proteins in the hypoxic response, we hypothesized that Rho family ... Related articles - All 3 versions
DJ Klemm, SM Majka, JT Crossno Jr… - Journal of …, 2011 - journals.lww.com Hypoxia-induced pulmonary arterial hypertension (PAH) is a deadly disease characterized by progressive remodeling and persistent vasoconstriction of the pulmonary arterial (PA) system. Remodeling of the PA involves smooth muscle cell (SMC) proliferation, ... All 3 versions
LA Palmer, WJ May, K deRonde… - American Journal of …, 2011 - Am Thoracic Soc ... Convention Center Ventilatory Responses During And Following Exposure To Hypoxia In Conscious Mice Deficient Or Null In S-Nitrosoglutathione Reductase ... Exposure to hypoxia elicits an increase in Minute Ventilation (MV) that diminishes with continued exposure (roll-off). ... All 3 versions