PA Grenier… - Diseases of the Heart and Chest, Including …, 2011 - Springer ... Asthma is a chronicinflammatory condition responsible for airway hyperresponsiveness to ... Over time, this inflam- matory disorder induces structural changes in airways (fi- brosis, smooth-muscle hypertrophia and hyperplasia, and neovessel formation), which lead to ...
E Dejonckheere, RE Vandenbroucke… - Cytokine & Growth Factor …, 2011 - Elsevier ... Besides degrading collagen, MMP8 can also modulate numerous inflammatory mediators. Second, lung disorders are associated with a high degree of oxidative stress, and MMP8 is highly ... MMP8 was proven to play an essential role in both acute and chronic lung disorders. ... Cited by 1 - Related articles - All 3 versions
A Sekiyama, Y Gon, M Terakado… - American Journal of …, 2011 - Am Thoracic Soc ... Nihon University School of Medicine, Tokyo, Japan 1 Asthma is a chronicinflammatorydisorder of the airway. Glucocorticoids (GCs) are by far the most effective anti-inflammatory therapy for asthma. Epithelial barrier damage is a cardinal feature of chronic asthma. ... All 3 versions
[PDF] from lonzabio.comS Damian, A Deighan, M Smithhisler… - Resource, 2011 - lonzabio.com ... Current drug targets of both diseases include certain enzymes or re- ceptors which are known to modulate key cells involved in regulating pathogenic immunity and inflammatory responses. ... Donors Diagnosed with Asthma or Chronic Obstructive Pulmonary Disorder (COPD) ...
S Borensztajn, H von der Thusen… - Current …, 2011 - ingentaconnect.com ... to play an essential role in idiopathic pulmonary fibrosis (IPF), whereas the role of PARs in other chronic pulmonary disorders like COPD ... while PAR-1 expression is strongly upregulated in macrophages and fibroblasts in fibroproliferative and inflammatory foci of ... Related articles - All 2 versions
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